Procarbazine

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Description

Procarbazine (commonly known by the brand name Matulane) is an oral chemotherapy medication. It is primarily used to treat stage III and IV Hodgkin’s disease and specific brain tumors (like glioblastoma). It destroys cancer cells by damaging their DNA and preventing replication. 
Key Details & Important Constraints
  • Pricing: U.S. cash prices average around $17,200 to $18,500 for a 100-capsule supply of 50 mg capsules. You can utilize GoodRx Matulane Coupons to explore discounts. International generic options are significantly lower, with accredited options starting at roughly $29 per capsule. 
  • Dietary Restrictions: Procarbazine is a weak MAO inhibitor. You must avoid alcohol and foods containing high amounts of tyramine (e.g., aged cheeses, deli meats, yeast, soy sauce, and pod beans) to prevent severe, sudden high blood pressure. 
  • Side Effects & Interactions: It commonly causes nausea, vomiting, and temporary hair loss. It also suppresses the bone marrow, lowering white blood cell, platelet, and red blood cell counts. Avoid any vaccinations while taking this medication without prior approval from your healthcare provider. 
  • Dosage: It is Procarbazine Oral Route – Mayo Clinic usually taken in cycles (often 100 mg/m² daily for 10 to 14 days) and should be taken after a light meal or at bedtime to help minimize stomach upset. 
For assistance with out-of-pocket costs and patient support programs, patients can refer to Drugs.com Matulane Price Guide or explore international suppliers through PharmacyChecker Procarbazine (Matulane).

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